Development of Novel Drug Delivery Systems for Antihypertensives
DOI:
https://doi.org/10.59890/ijir.v3i7.52Keywords:
Hypertension, Drug Delivery Systems, Nanotechnology, Transdermal Patches, Sustained-Release, Patient Adherence, Pharmacokinetics, Microneedles, Antihypertensive Therapy, Targeted DeliveryAbstract
This review explores innovative approaches, including transdermal patches, oral sustained-release formulations, nanoparticles, liposomes, and microneedle-based systems, all designed to enhance the efficacy, safety, and patient compliance of antihypertensive therapy. Nanotechnology-based systems, in particular, have demonstrated the ability to improve solubility and targeted delivery, reducing systemic side effects and enhancing the pharmacokinetic profile of conventional drugs such as amlodipine, losartan, and enalapril. Transdermal delivery systems bypass first-pass metabolism and offer steady plasma drug levels, reducing fluctuations that contribute to adverse effects. Furthermore, microneedle technology is gaining attention for painless, minimally invasive delivery with controlled release capabilities. While these novel systems offer considerable advantages, challenges remain, including formulation stability, scalability, and regulatory approval. Continued research is essential to validate the long-term efficacy and safety of these technologies through clinical trials. Integration of these novel drug delivery platforms may revolutionize the treatment landscape of hypertension by optimizing drug effectiveness, reducing dosing frequency, and enhancing patient adherence, ultimately improving cardiovascular outcomes and quality of life in hypertensive populations
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Copyright (c) 2025 Rehan Haider, Zameer Ahmed, Geetha Kumari Das, Sambreen Zameer
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