Profiling of Bioactive Compound in Convolvulus Cneorum Essential Oil by Gas Chromatography/Mass Spectrometry Analysis

Alagbe J.O

doi:10.59890/ijir.v3i12.112

Authors

Alagbe J.O Gandhi College of Agriculture

DOI:

https://doi.org/10.59890/ijir.v3i12.112

Keywords:

Antimicrobial, Antioxidant, Inflammatory, Essential Oil, Pharmacology

Abstract

Convolvulus cneorum essential oil is packed with bioactive chemistry, its leaves harbors molecules that protects pain, reduces inflammation, reduces oxidative stress, neutralize free radicals, microbial infections and restores vitality in the body. Its unique spectrum of bioactive compounds also provides broad-spectrum antimicrobial, antifungal, antiviral, antidiabetic, hepato-protective, antidiarrheal, anticancer, anti-tumor, hypo-lipidemic activity amongst others. The herbal plant stands as a bridge between traditional and modern pharmacology. GC/MS analysis of Convolvulus cneorum essential oil revealed the presence of 39 bioactive compounds and the predominant compounds includes; Alpha--murolene (18.96 %), α-terpinene (18.07 %), 1,8-cineole (10.44 %) and β-caryophyllene (10.04 %). The synergy between other compounds in the oil forms a medicinal library that can also be used to curb the increasing cases of antimicrobial resistance. In conclusion, Convolvulus cneorum essential oil remains a living example of validated pharmacological medicinal plant with measurable anti-inflammatory and antioxidant therapy

References

Adewale AO, Alagbe JO, Adeoye, AO. Dietary Supplementation of Rauvolfia Vomitoria Root Extract as A Phytogenic Feed Additive in Growing Rabbit Diets: Haematology and serum biochemical indices. International Journal of Orange Technologies, 2021; 3(3): 1-12.

Alagbe JO, Shittu MD, Tanimomo, Babatunde K. Influence of Anogeissusleio carpus stem bark on the fatty acid composition in meat of broiler chickens. European Journal of Life Safety and Stability 2022; 14(22): 13-22.

Alagbe JO, Zubairu H, Adedeji OM, Bamigboye S, Dora A. Influence of Juniperus thurifera root extract on the nutrient digestibility and caecal microbial count of growing rabbits. Web of Synergy: International Interdisciplinary Res Jou. 2022; 1(1): 5-17.

Alagbe JO. (2022). Gas chromatography and mass spectroscopy of Juniperus phoenice stem bark extract and its influence on the haemato-biochemical values of growing rabbits. British Scientific Period. 2022; 1(1): 18-33.

Alagbe JO. Use of medicinal plants as a panacea to poultry production and food security: A review. Gospodarka I Innowacje 22(2022): 1-12.

Alagbe OJ. Novel phytogenics’ impact on weaned pigs growth performance, haematology and serum biochemical indicators. Black Sea Journal of Agriculture, 2024; 7(2): 82-89.

Alagbe, J.O. (2025). Accessing the Qualitative and Bioactive Compounds in the leaves of Withania somnifera from Rajasthan India. Journal of Clinical and Laboratory Research, 8(4): 1-8.

Alagbe, J.O. (2025). Effect of Heliotropium indicum leaf powder supplemented diets on growth performance and carcass characteristics of weaned pigs. Journal of Applied and Advanced Multidisciplinary Research, 3(1): 13-24.

Alagbe, J.O. (2025). Evaluation of bioactive compounds in Schizomussaenda henryi oil by Gas Chromatography and Mass Spectrometry. Journal of Applied and Advanced Multidisciplinary Research, 3(9): 661-668.

Amrati, FEZ., Bourhia, M., Saghrouchni, H., Sighoua, M., and Grafov, A Caralluma Europaea (Guss.) NE Br. (2021). Anti-Inflammatory, Antifungal, and Antibacterial Activities against Nosocomial Antibiotic-Resistant Microbes of Chemically Characterized Fractions. Molecules. Issue. 26, pp. 636, 2021.

Arora, M., and Malhotra, M. A (2011). Review on macroscopical, phytochemical and biological studies on Convolvulus arvensis (field bindweed). Pharmacology online.Vol. 3, pp. 1296-1305, 2011.

Ashraf, I., Zubair, M., Rizwan, K., Rasool, N., Jamil, M., Khan, S.A.; and Tareen, R.B. (2018). Chemical composition, antioxidant and antimicrobial potential of essential oils from different parts of Daphne mucronata Royle. Chem Cent J. Dec. Vol. 17, Issue. 12, pp. 135, 2018.

Azman, N. A., Gallego, M. G., Julia, L.; Fajari, L., and Almajano, M. (2015). The effect of Convolvulus arvensis dried extract as a potential antioxidant in food models. Antioxidants (Basel), Vol. 4, Issue. 1 , pp. 170–184, 2015.

Boulos, L. (2000). Flora of Egypt, (Convolvulacea). Al hadar publishing, Cairo, Egypt, Vol. 2, pp. 352, 2000.

Chen, G.T.; Lu, Y.; Yang, M.; Li, J.-L.; Fan, B.-Y. (2018). Medicinal Uses, Pharmacology, and Phytochemistry of Convolvulaceae Plants with Central Nervous System Efficacies: A Systematic Review. Phytother. Res, Vol. 32, pp. 823–864, 2018.

Daniel NA, Friday U, Alagbe Olujimi John. Investigating the effects of pawpaw (Carica papaya) essential oil dietary supplementation on the growth performance and carcass characteristics of broilers. Research in: Agricultural and Veterinary Sciences, 2023; 7(3): 164 - 174.

Elzaawel, Y. A and Tawata, S. (2012). Antioxidant activity of phenolic rich fraction obtained from Convolvulus arvensis L. leaves grown in Egypt. Asian Journal of Crop Science. pp. 432-40, 2012.

Emile Acha., Judith F Anounou Aïkpe., Jacques Adoverlande., M Fidèle Assogba, Grégoire Agossou, Alphonse Sezan, H Pierre Dansou and Joachim D Gbenou (2019). Anti-inflammatory Properties of Melaleuca Quinquenervia (Cav.) ST Blake Myrtaceae (Niaouli) Leaves’ Essential Oil. Journal of Chemical and Pharmaceutical Research, 11(1): 36-50.

Hanoch Julianus Sohilait, Healthy Kainama. (2016) GC/GC-MS Analysis, Isolation and Identification of Bark Essential Oil Components from Cinnamomum culilawan, Blume. American Journal of Applied Chemistry. 4(4): 157-160.

Hassan, K. K. (2012). Cytotoxic and cytogenetic effects of some extracts of Convolvulus arvensis on tumor and transformed cell lines in vitro, 2012.

Hassine, M.; Berguaoui, A., Znati, M., Flamini, G., Ben jannet, H., and Hamza, M. A. (2014). Chemical composition, antibacterial and cytotoxic activities of the essential oil from the flowers of Tunisian Convolvulus althaeoides L. Natural Product Research, Vol. 28, Issue. 11, pp. 769–775, 2014.

Hernandez M, Alagbe JO. (2025a). Influence of Abrus procatorious crude oil supplementation on the growth performance, Nutrient digestibility, Ruminal fermentation and Microbial population of Malabari Bucks. International Journal of Global Sustainable Res. 2025a; 3(7): 527-538

Hernandez M, Alagbe JO. (2025b). Influence of Odontonema strictum oil on the growth performance and Ruminal fermentation of Barbari bucks. Research in: Agriculture and Veterinary Sci. 2025b; 9(2):1-10.

Inikpi, E., Lawal, O. A., Ogunmoye, A.O., and Ogunwande, I. A. (2014). Volatile composition of the floral essential oil of Hibiscus sabdariffa L. from Nigeria. American Journal of Essential Oils and Natural Products; Vol. 2, Issue. 2, 04-07, 2014.

John AO. Clerodendron splendens leaf extract supplementation in weaner rabbits: impact on growth performance, haematology and intestinal microbial population. Cerrado: Agricultural and Biological Research, 2024b;1(1): 21-31.

John AO. Effect of coconut shell extract on the growth performance and some haemato-biochemical parameters of broiler chicken. Brazilian Journal of Science, 2024c; 3(6): 82-95.

John AO. Effect of performance, serum biochemistry and heamatological components of feeding Japanese quails phytogenic feed additions comprising Megaphrynium macrostachyum leaves. Brazilian Journal of Science, 2024d; 3(5): 51-64.

John AO. Impact of dietary supplementation of Rhamnus prinoides leaf extract on the growth performance, nutrient retention and intestinal microbial count of Japanese quails. Brazilian Journal of Science, 2024a; 3(5): 40-50.

Kaur, M., & Kalia, A. N. (2012). Anticancer potential of the Convolvulus arvensis. International Journal of Pharmaceutical Research & Allied Sciences, Vol. 1, Issue. 3, pp. 101–102, 2012.

Luo Y, LuoYo, Chen F, Liu H. (2014). Studies on the Chemical constituents in the essential oils from the leaves of Cinnamomum bodinieri Levi, Adv. Meterials Res., 2014, 1015, 373-376.

Mayada Mahmoud Zahlout (2024). A study to determine chemical composition of Convolvulus althaeoides L. Plant by using (GC-MS). International Journal of Scientific Research in Chemical Sciences, 11(4): 23-27

Mishra, S.H., and Sethiya, N.K. (2010). Review on Ethnomedicinal Uses and Phytopharmacology of Memory Boosting Herb’Convolvulus Pluricaulis’ Choisy. Aust. J. Med. Herbal, Vol. 22, pp. 19–25, 2010.

Muritala, DS, Daniel Shittu, Alagbe, JO, Ojebiyi OO, Ojediran TK, Rafiu TA. Growth performance and haematological and serum biochemical parameters of broiler chickens given varied concentrations of Polyalthia longifolia leaf extract in place of conventional antibiotics. Animal Science and Genetics 2022; 18(2): 57-71.

Musa B, Alagbe JO, Adegbite MB, Omokore EA. Growth performance, caeca microbial population and immune response of broiler chicks fed aqueous extract of Balanites aegyptiaca and Alchornea cordifolia stem bark mixture. United Journal for Research and Technology, 2020; 2(2):13-21.

NIST. Chemistry Web Book. Data from NIST Standard Reference Database 69, 2011.

Ojediran TK, Emiola IA, Durojaye V, John O.A. Proximate, vitamin and GC-MS profiling of Kigella africana powder. Cerrado: Agricultural and Biological Research, 2024; 1(1): 13-20.

Ojediran TK, Emiola IA, Durojaye, V, Alagbe, JO. Analysis of Kigellia africana fruit’s powder antioxidant and phytochemical properties. Brazilian Journal of Science, 2024; 3(7): 38-49.

Oluwafemi RA, Lawal A.O, Adelowo SA, Alagbe JO. Effects of dietary inclusion of ginger (Zingiber officinale) and garlic (Allium sativum) oil on carcass characteristics and sensory evaluation of broiler chicken. Texas Journal of Multidisciplinary Stud. 2021; 2(11): 180-188

Omokore EO, Alagbe, JO. Efficacy of dried Phyllantus amarus leaf meal as an herbal feed additive on the growth performance, haematology and serum biochemistry of growing rabbits. International Journal of Academic Research and Development.2019; 4(3): 97-104.

Salamatullah, A.M. (2022). "Convolvulus arvensis: Antioxidant, Antibacterial, and Antifungal Properties of Chemically Profiled Essential Oils: An Approach against Nosocomial Infections. Life, Vol. 12, pp. 2138, 2022.

Saleem, M., Qadir, M., Ahmad, B., Saleem, D. U., Naseer, F., Schini‐Kerth, V., and Hussain, K. Cytotoxic effect of ethanol extract of Convolvulu arvensis L (Convolvulaceae) on lymphoblastic leukemia Jurkat cells. Tropical Journal of Pharmaceutical Research, Vol. 13, pp. 705–709, 2014.

Shittu MD, Alagbe JO, Alaba O, Okanlawon EO, Adelakun FA, Emmanuel EO and Adejumo DO. Effect of ginger, garlic and Negro pepper on the gut microbes, gut histomorphometry and pathological assessment of selected organs of broiler chickens. Association of Deans of Agriculture in Nigerian Universities, 2024; 5: 105-121.

Shittu MD, Alagbe JO. (2020) Phyto-nutritional profiles of broom weed (Sida acuta) leaf extract. International Journal of Integrated Edu 2020; 3(11): 119-124

Singh AS, Alagbe JO, Sharma S, Oluwafemi RA, Agubosi OCP. Effect of dietary supplementation of melon (Citrallus linatus) seed oil on the growth performance and antioxidant status of growing rabbits. Journal of Multidimensional Research and Rev. 2021; 2(1): 78-95.

Singh S, Alagbe OJ, Liu X, Sharma R, Kumar A. Comparative analysis of ethanolic Juniperus thurifera leaf, stem bark and root extract using gas chromatography and mass spectroemetry. International Journal of Agriculture and Animal Prod. 2022; 2(6): 18-27.